3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate
(S)-(-)-3-Tert-Butoxycarbonyl-4-Methoxycarbonyl-2,2-Dimethyl-1,3-Oxazolidine
CAS: 108149-60-6
Molecular Formula: C12H21NO5
3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate - Names and Identifiers
3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate - Physico-chemical Properties
| Molecular Formula | C12H21NO5 |
| Molar Mass | 259.3 |
| Density | 1.082g/mLat 25°C(lit.) |
| Boling Point | 101-102°C2mm Hg(lit.) |
| Flash Point | 199°F |
| Vapor Presure | 0.000629mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow |
| pKa | -3.58±0.60(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.443(lit.) |
| MDL | MFCD00192279 |
| Physical and Chemical Properties | WGK Germany:3 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 29349990 |
3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate - Reference Information
| Use | (S)-(-)-3-boc-4-methoxycarbonyl-2, 2-dimethyl-1, 3-oxazolidine is a useful intermediate for improving the synthesis of Ganal and its analogs, with a variety of pharmaceutical applications. At present, organic compounds containing oxazole ring as drugs have been widely used in clinical, and play an irreplaceable role in overcoming clinical drug resistance and treating infectious diseases. |
| preparation | the target compound (S) was prepared by one-pot reaction with ethanolamine, acetone and di-tert-butyl dicarbonate as starting materials.-(-)-3-boc-4-methoxycarbonyl-2, 2-dimethyl-1, 3-oxazolidine. The synthesis reaction scheme is as shown below: experimental procedure a thermometer, a dropping funnel and a condenser are respectively set on a 100ml dry three-diameter round-bottom flask, and ethanolamine, acetone and benzene are sequentially added thereto, followed by stirring at 35 ° C. For 30 minutes.. The reaction system is cooled to -10 ℃ with ice salt bath, and sodium hydroxide aqueous solution is added and stirred. When the reaction temperature drops to -5 ℃, di-tert-butyl dicarbonate is slowly added dropwise, and the temperature of the system is controlled to 0 ℃, the dropwise addition was completed in about 40 minutes, and stirring was continued for 1 hour. The reaction solution was washed with water until neutral, dried over anhydrous magnesium sulfate, the solvent was distilled off, and the solid was recrystallized from ethyl acetate/petroleum ether to obtain product (S)-(-)-3-boc-4-methoxycarbonyl-2, 2-dimethyl-1, 3-oxazolidine. |
Last Update：2024-04-09 21:22:08
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Product Name: (S)-(-)-3-Boc-4-Methoxycarbonyl-2,2-Dimethyl-1,3-Oxazolidine Visit Supplier Webpage Request for quotation
CAS: 108149-60-6
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3-(1,1-Dimethylethyl)-4-Methyl-(S)-2,2-Dimethyl-3,4-Oxazolidine Carboxylate
Dimethylethylphosphine sulfide
4-甲氧基-3-甲基苯基硼酸
Dimethylethylphosphine sulfide
4-甲氧基-3-甲基苯基硼酸